|
KMID : 0606920100180020166
|
|
Biomolecules & Therapeutics
2010 Volume.18 No. 2 p.166 ~ p.170
|
|
|
The Modulation of Motility of Pyloric Antral Smooth Muscles of Rat by Melatonin
|
|
Han Sang-Hoon
Lee Da-Woon
Cho Soo-Hyun
Kim June-Sun
|
|
|
Abstract
|
|
|
|
Recently some researches have established that the melatonin, secreted by pineal gland, may evoke the changes of contractile responses on smooth muscles. We examined the effects of melatonin on the motility of rat pyloric antrum and which mechanism might be involved in the effects. Pyloric antral strips from the stomach of 20 Sprague-Dawley rats were prepared for isometric tension recording in organ bath. The strips were precontracted by acetylcholine and high-KCl solutions. In precontracted conditions the tensions were increased by accumulative application of melatonin (10?8-10?4 M) dose-dependently, even in resting states. And the effects were almost disappeared when the concentrations of ACh were over than 10 μM. The effects of melatonin were inhibited by pretreatment of 10 mM TEA and/or 10 μM 4-AP and rarely affected by pretreatment of 1 mM TEA, 10 μM glibenclamide and 10 μM verapamil respectively. From these results it is concluded that the contractile responses of smooth muscles of rat pyloric antrum were enhanced by melatonin application and the mechanism might be concerned with the inhibition of some voltage-dependent potassium channels.
|
|
|
KEYWORD
|
|
|
Melatonin, Smooth muscle, Pyloric antrum, Potassium channel
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|